HGS polyclonal (N-term), anti-human, mouse
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In stock
SKU
AC-AP2161a
Catalog Number: AC-AP2161a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB4400
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB4400
Applications: IHC-P, WB
Datasheet
Request Information
Background:
HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
Other Names:
Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110, HGS, HRS
Target/Specificity:
This HGS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the N-terminal region of human HGS.
Antigen Region:
256-286
Antigen Type: Synthetic Peptide
Gene Name: HGS
Gene ID: 9146
Primary Accession: O14964
NCBI Accession: NP_004703.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
Other Names:
Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110, HGS, HRS
Target/Specificity:
This HGS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the N-terminal region of human HGS.
Antigen Region:
256-286
Antigen Type: Synthetic Peptide
Gene Name: HGS
Gene ID: 9146
Primary Accession: O14964
NCBI Accession: NP_004703.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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