hHER4 polyclonal (C-term Y1188), anti-human

Background:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Other Names:
Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, ERBB4, HER4

Target/Specificity:
This hHER4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1169-1194 amino acids from the C-terminal region of human hHER4.

Antigen Region:
1169-1194

Antigen Type: Synthetic Peptide

Gene Name: ERBB4
Gene ID: 2066
Primary Accession: Q15303
NCBI Accession: NP_001036064.1;NP_005226.1
Other Accession: NP_001036064.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.