HIC2 polyclonal, anti-human, mouse
€305.00
In stock
SKU
BS60430
Background:
HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
Alternative Name:
Hypermethylated in cancer 2 protein, Hic-2, HIC1-related gene on chromosome 22 protein Hic-3, Zinc finger and BTB domain-containing protein 30, HIC2, HRG22, KIAA1020, ZBTB30
Application Dilution: WB: 1:500~1:1000
Specificity: HIC2 polyclonal antibody detects endogenous levels of HIC2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human HIC2.
MW: ~ 72 kDa
Swis Prot.: Q96JB3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
Alternative Name:
Hypermethylated in cancer 2 protein, Hic-2, HIC1-related gene on chromosome 22 protein Hic-3, Zinc finger and BTB domain-containing protein 30, HIC2, HRG22, KIAA1020, ZBTB30
Application Dilution: WB: 1:500~1:1000
Specificity: HIC2 polyclonal antibody detects endogenous levels of HIC2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human HIC2.
MW: ~ 72 kDa
Swis Prot.: Q96JB3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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