HIF1 alpha Polyclonal Antibody

Background:
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
ARNT interacting protein, ARNT-interacting protein, Basic helix loop helix PAS protein MOP1, Basic-helix-loop-helix-PAS protein MOP1, bHLHe78, Class E basic helix-loop-helix protein 78, HIF 1A, HIF 1alpha, HIF-1-alpha, HIF1 A, HIF1 Alpha, HIF1, HIF1-alpha, HIF1A, HIF1A, Hypoxia inducible factor 1 alpha, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor), Hypoxia inducible factor1alpha, Hypoxia-inducible factor 1-alpha, Member of PAS protein 1, Member of PAS superfamily 1, Member of the PAS Superfamily 1, MOP 1, MOP1, PAS domain-containing protein 8, PASD 8, PASD8

Immunogen: Synthetic peptide of human HIF1A

Swissprot: Q16665
Gene Accession: NP_001230013

Calculated MW: 93 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-12542/sc-8711/sc-10790

Citation(s):
https://www.sciencedirect.com/science/article/pii/S1874939918305248
https://assets.researchsquare.com/files/752b91bd-5876-4f2c-b2b8-1f78337cb0ee/v2/Manuscript.pdf