HIF3 polyclonal, anti-rat, human

Quantity: 100 µg

Background:
Hypoxia-inducible factor 3 alpha, also called MOP7, is a protein that in humans is encoded by the HIF3A gene. HIF3A is mapped to 19q13.32. This gene involved in adaptive response to hypoxia. HIF3A suppresses hypoxia-inducible expression of HIF1A and EPAS1. It binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element(HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. This gene functions as an inhibitor of angiogenesis in the cornea.

Description:
Rabbit IgG polyclonal antibody for Hypoxia-inducible factor 3-alpha (HIF3A) detection. Tested with WB in Human, Rat.

Synonyms:
Basic-helix-loop-helix-PAS protein MOP7 antibody, bHLHe17 antibody, Class E basic helix-loop-helix protein 17 antibody, HIF 3A antibody, HIF 3A4 antibody, HIF-3-alpha antibody, HIF3 alpha antibody, HIF3-alpha antibody, HIF3-alpha-1 antibody, HIF3A antibody, HIF3A_HUMAN antibody, Hypoxia Inducible Factor 3 alpha antibody, Hypoxia inducible factor 3 alpha subunit antibody, Hypoxia inducible factor three alpha antibody, Hypoxia-inducible factor 3-alpha antibody, Inhibitory PAS domain protein antibody, IPAS antibody, Member of PAS protein 7 antibody, MOP7 antibody, PAS domain-containing protein 7 antibody, PASD7 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human HIF3(497-514aa DDDFQLNASEQLPRAYHR), different from the related rat and mouse sequences by five amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of human HIF3(497-514aa DDDFQLNASEQLPRAYHR), different from the related rat and mouse sequences by five amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: human.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.