HIRA Polyclonal Antibody

Background:
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells

Synonyms:
HIRA, DGCR1, TUP1, TUPLE1

Immunogen: Recombinant fusion protein of human HIRA (NP_003316.3).

Swissprot: P54198
Gene ID: 7290

Calculated MW: 89 kDa/111 kDa
Observed MW: 112 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:100-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.