HIST1H2BM Blocking Peptide (Center)

Background:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Other Names:
Histone H2B type 1-M, Histone H2Be, H2B/e, HIST1H2BM, H2BFE

Target/Specificity:
The synthetic peptide sequence is selected from aa 44-58 of HUMAN HIST1H2BM

Gene Name: H2BC14 (HGNC:4750)

Gene ID: 8342
Primary Accession: Q99879
Other Accession: P02283; P57053; Q9PSW9; P0C1H5; P0C1H4; Q6PC60; Q8CGP0; Q8N257; Q9D2U9; Q5QNW6; Q64524; Q16778; Q64525; Q00715; Q5BJA5; P0C1H3; P62808; Q8CGP2; P23527; Q99877; Q32L48; P10854; Q99880; Q8CGP1; O60814; Q2M2T1; P06899; Q64478; Q93079; P10853; P58876; Q6ZWY9;
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.