HIST3H3 polyclonal, anti-human, mouse

Background:
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.

Synonyms: Histone H3.3, H3.3 , H3.3A, H3.3B, H3F3A

Cellular Location: Nucleus

Immunogen:
A synthetic peptide of human HIST3H3

Gene Symbol: HIST3H3

Gene ID: 8350

Swiss prot: P06353

Calculated MW: 17kDa

Recommended dilution:
WB 1:500-2000, IHC 1:25-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.