Histone H2A.X (phospho-S139) (clone ), anti-human, mouse
€388.00
In stock
SKU
MB0175
Background:
H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.
Alternative Name:
Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX, γ-H2AX, γH2AX, ganunaH2AX, γ-H2A.X, γH2A.X, ganunaH2A.X
Application Dilution: WB: 1:1000~2000, IF: 1:200~500
Specificity: This antibody detects endogenous levels of Histone H2A.X protein only when phosphorylated at Ser139, and does not cross-react with related proteins.
Immunogen:
Synthetic phosphopeptide derived from human Histone H2A.X around the phosphorylation site of Serine 139.
MW: Predicted band size: 15KDa , Observed band size: 15KDa
Swis Prot.: P16104
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.
Alternative Name:
Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX, γ-H2AX, γH2AX, ganunaH2AX, γ-H2A.X, γH2A.X, ganunaH2A.X
Application Dilution: WB: 1:1000~2000, IF: 1:200~500
Specificity: This antibody detects endogenous levels of Histone H2A.X protein only when phosphorylated at Ser139, and does not cross-react with related proteins.
Immunogen:
Synthetic phosphopeptide derived from human Histone H2A.X around the phosphorylation site of Serine 139.
MW: Predicted band size: 15KDa , Observed band size: 15KDa
Swis Prot.: P16104
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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