Histone H2A.X (Ser139) Blocking Peptide
€363.00
In stock
SKU
AC-BP20702b
Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
Other Names:
Histone H2AX, H2a/x, Histone H2AX, H2AFX, H2AX
Target/Specificity:
The synthetic peptide sequence is selected from aa 134-143 of HUMAN H2AFX
Gene Name: H2AX (HGNC:4739)
Gene ID: 3014
Primary Accession: P16104
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
Other Names:
Histone H2AX, H2a/x, Histone H2AX, H2AFX, H2AX
Target/Specificity:
The synthetic peptide sequence is selected from aa 134-143 of HUMAN H2AFX
Gene Name: H2AX (HGNC:4739)
Gene ID: 3014
Primary Accession: P16104
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review