Histone H2A.Z (Acetyl Lys14) Rabbit polyclonal antibody, anti-human, mouse, rat
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In stock
SKU
BT-AP10413
Catalog Number: BT-AP10413
Size(s): 20μL, 50μL, 100μL
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Application(s): WB, ELISA
Datasheet
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Size(s): 20μL, 50μL, 100μL
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Application(s): WB, ELISA
Datasheet
Request Information
Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.|mass spectrometry:Monoisotopic| not modified PubMed:16457589|PTM:Acetylated on Lys-5| Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.|PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|PTM:Not phosphorylated.|Belongs to the histone H2A family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.|
Research Area: Epigenetics and nuclear signaling
Synonyms: Histone H2A.Z , Acetyl Lys14, Histone H2A.Z, H2A/z
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage:
-20°C for 1 year
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.|mass spectrometry:Monoisotopic| not modified PubMed:16457589|PTM:Acetylated on Lys-5| Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.|PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|PTM:Not phosphorylated.|Belongs to the histone H2A family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.|
Research Area: Epigenetics and nuclear signaling
Synonyms: Histone H2A.Z , Acetyl Lys14, Histone H2A.Z, H2A/z
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage:
-20°C for 1 year
| Is Featured? | No |
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