Histone H2AX (clone ), anti-human antibody

Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Other Names:
H3F3A, H3.3A, H3F3, H3F3B, H3.3B

Primary Accession: P16104

Gene Name: H2AX (HGNC:4739)

Gene ID: 3014

Concentration (mg/ml): 1 mg/ml