Histone H2B polyclonal antibody, anti-human, mouse, rat

Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Research Area: Epigenetics and nuclear signaling

Synonyms: Histone H2B type 1-C/E/F/G/I/Histone H2B type 1-D/Histone H2B type 1-H/Histone H2B type 1-K/Histone H2B type 1-L/Histone H2B type 1-M/Histone H2B type 1-N/Histone H2B type 2-F/Histone H2B type F-S, HIST1H2BB, H2BFF, Histone H2B type 1-B, Histone H2B.1, Histone H2B.f, H2B/f, HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2BI, H2BFK, Histone H2B type 1-C/E/F/G/I, Histone H2B.1 A, Histone H2B.a, H2B/a, Histone H2B.g, H2B/g, Histone H2B.h, H2B/h, Histone H2B.k, H2B/k, Histone H2B.l, H2B/l, HIST1H2BD, H2BFB, HIRIP2, Histone H2B type 1-D, HIRA-interacting protein 2, Histone H2B.1 B, Histone H2B.b, H2B/b, HIST1H2BH, H2BFJ, Histone H2B type 1-H, Histone H2B.j, H2B/j, HIST1H2BJ, H2BFR, Histone H2B type 1-J, Histone H2B.1, Histone H2B.r, H2B/r, HIST1H2BK, H2BFT, HIRIP1, Histone H2B type 1-K, H2B K, HIRA-interacting protein 1, HIST1H2BL, H2BFC, Histone H2B type 1-L, Histone H2B.c, H2B/c, HIST1H2BM, H2BFE, Histone H2B type 1-M, Histone H2B.e, H2B/e, HIST1H2BN, H2BFD, Histone H2B type 1-N, H

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year