Histone H3.3 H3F3A monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO14122
Catalog Number: AC-ABO14122
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC
Datasheet
Request Information
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC
Datasheet
Request Information
Description: Anti-Histone H3.3 H3F3A Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
Other Names: Histone H3.3, H3-3A (HGNC:4764), H3.3A, H3F3, H3F3A
Clone Name(s):
Clone: EBF-8
Subcellular Localization: Nucleus. Chromosome.
Gene ID: 3020;3021
Immunogen: A synthesized peptide derived from human Histone H3.3
Calculated MW: 15328
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
Other Names: Histone H3.3, H3-3A (HGNC:4764), H3.3A, H3F3, H3F3A
Clone Name(s):
Clone: EBF-8
Subcellular Localization: Nucleus. Chromosome.
Gene ID: 3020;3021
Immunogen: A synthesized peptide derived from human Histone H3.3
Calculated MW: 15328
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
| Is Featured? | No |
|---|
Write Your Own Review