Histone H4 Polyclonal Antibody

Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
H4, H4F2, H4FN, HIST1H4, HIST2H4, Hist4h4, HISTH4H4, Histone H4, methyl histone H4, methylated histone H4

Immunogen: Recombinant protein corresponding to human Histone H4

Swissprot: P62805

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 1.8 mg/mL
Dilution: IHC 1:300-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.