HK1 (Hexokinase) polyclonal (N-term), anti-human, rat
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In stock
SKU
AC-AP8141a
Catalog Number: AC-AP8141a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB3921/RB3922
Applications: WB, IHC-P-Leica
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB3921/RB3922
Applications: WB, IHC-P-Leica
Datasheet
Request Information
Background:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.
Other Names:
Hexokinase-1, Brain form hexokinase, Hexokinase type I, HK I, HK1
Target/Specificity:
This HK1 (Hexokinase) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human HK1 (Hexokinase).
Antigen Region:
78-108
Antigen Type: Synthetic Peptide
Gene Name: HK1 (HGNC:4922)
Gene ID: 3098
Primary Accession: P19367
NCBI Accession: NP_000179.2;NP_277031.1;NP_277032.1;NP_277033.1;NP_277035.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.
Other Names:
Hexokinase-1, Brain form hexokinase, Hexokinase type I, HK I, HK1
Target/Specificity:
This HK1 (Hexokinase) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human HK1 (Hexokinase).
Antigen Region:
78-108
Antigen Type: Synthetic Peptide
Gene Name: HK1 (HGNC:4922)
Gene ID: 3098
Primary Accession: P19367
NCBI Accession: NP_000179.2;NP_277031.1;NP_277032.1;NP_277033.1;NP_277035.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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