HK2 (Hexokinase II) (Center) polyclonal, anti-human antibody
€355.00
In stock
SKU
AC-ABV10116-100
Catalog Number: AC-ABV10116-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
Request Information
Background:
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Altho µgh found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
Other Names:
Hexokinase type II, HK II, Muscle form hexokinase
Primary Accession: P52789
Gene Name: HK2 (HGNC:4923)
Gene ID: 3099
Concentration (mg/ml): 0.25 mg/ml
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Altho µgh found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
Other Names:
Hexokinase type II, HK II, Muscle form hexokinase
Primary Accession: P52789
Gene Name: HK2 (HGNC:4923)
Gene ID: 3099
Concentration (mg/ml): 0.25 mg/ml
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