HK2 (Hexokinase II) polyclonal (Center), anti-human
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In stock
SKU
AC-AP8140c
Catalog Number: AC-AP8140c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB03920
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB03920
Applications: IHC-P, WB
Datasheet
Request Information
Background:
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
Other Names:
Hexokinase-2, Hexokinase type II, HK II, Muscle form hexokinase, HK2
Target/Specificity:
This HK2 (Hexokinase II) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-431 amino acids from the Central region of human HK2 (Hexokinase II).
Antigen Region:
401-431
Antigen Type: Synthetic Peptide
Gene Name: HK2 (HGNC:4923)
Gene ID: 3099
Primary Accession: P52789
NCBI Accession: NP_000180.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
Other Names:
Hexokinase-2, Hexokinase type II, HK II, Muscle form hexokinase, HK2
Target/Specificity:
This HK2 (Hexokinase II) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-431 amino acids from the Central region of human HK2 (Hexokinase II).
Antigen Region:
401-431
Antigen Type: Synthetic Peptide
Gene Name: HK2 (HGNC:4923)
Gene ID: 3099
Primary Accession: P52789
NCBI Accession: NP_000180.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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