HLA-A (MHC I) (clone 108-2C5 ), anti-human
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In stock
SKU
AC-AH11402
Catalog Number: AC-AH11402
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: 108-2C5
Applications: IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: 108-2C5
Applications: IF, FC
Datasheet
Request Information
Background:
HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and �Aw33). Its epitope maps between aa65-to-aa80 of the ?1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.
Other Names:
HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLA-B, HLAB
Gene Name: HLA-B (HGNC:4932)
Gene ID: 3106
Primary Accession: P01889
Other Accession: 3105, 181244, 654404, 77961,P30443,P30499
HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and �Aw33). Its epitope maps between aa65-to-aa80 of the ?1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.
Other Names:
HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLA-B, HLAB
Gene Name: HLA-B (HGNC:4932)
Gene ID: 3106
Primary Accession: P01889
Other Accession: 3105, 181244, 654404, 77961,P30443,P30499
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