HLA-C polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.

Description:
Rabbit IgG polyclonal antibody for MHC class I antigen (HLA-C) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
1C07_HUMAN antibody, Cw-7 alpha chain antibody, D6S204 antibody, HLA class I histocompatibility antigen antibody, HLA class I histocompatibility antigen, C alpha chain antibody, HLA class I histocompatibility antigen, Cw-1 alpha chain antibody, HLA-C antibodyHLA-C histocompatibility type antibody, HLA-Cw antibody, HLA-JY3 antibody, HLAC antibody, HLC-C antibody, human leukocyte antigen-C alpha chain antibody, major histocompatibility antigen HLA-C antibody, major histocompatibility complex, class I, C antibody, MHC class I antigen antibody, MHC class I antigen Cw 1 antibody, MHC class I antigen Cw*7 antibody, MHC class I antigen heavy chain HLA-C antibody, PSORS1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human HLA-C(38-62aa EYWDRETQKYKRQAQADRVNLRKLR).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.