HLA-C polyclonal (Center), anti-human
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In stock
SKU
AC-AP17872c
Catalog Number: AC-AP17872c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB21680
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB21680
Applications: WB
Datasheet
Request Information
Background:
HLA-C belongs to the HLA class I heavy chain paralogues.This class I molecule is a heterodimer consisting of a heavy chainand a light chain (beta-2 microglobulin). The heavy chain isanchored in the membrane. Class I molecules play a central role inthe immune system by presenting peptides derived from endoplasmicreticulum lumen. They are expressed in nearly all cells. The heavychain is approximately 45 kDa and its gene contains 8 exons. Exonone encodes the leader peptide, exons 2 and 3 encode the alpha1 andalpha2 domain, which both bind the peptide, exon 4 encodes thealpha3 domain, exon 5 encodes the transmembrane region, and exons 6and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 andexon 3 are responsible for the peptide binding specificity of eachclass one molecule. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. Over one hundredHLA-C alleles have been described
Other Names:
HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7, HLA-C, HLAC
Target/Specificity:
This HLA-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
Antigen Region:
66-93
Antigen Type: Synthetic Peptide
Gene Name: HLA-C (HGNC:4933)
Gene ID: 3107
Primary Accession: P10321
NCBI Accession: NP_002108.4
Other Accession: Q29865; Q95604; Q29960; P30510; P30508; P30505; Q29963; Q9TNN7; P30504; P04222; P30484; NP_002108.4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
HLA-C belongs to the HLA class I heavy chain paralogues.This class I molecule is a heterodimer consisting of a heavy chainand a light chain (beta-2 microglobulin). The heavy chain isanchored in the membrane. Class I molecules play a central role inthe immune system by presenting peptides derived from endoplasmicreticulum lumen. They are expressed in nearly all cells. The heavychain is approximately 45 kDa and its gene contains 8 exons. Exonone encodes the leader peptide, exons 2 and 3 encode the alpha1 andalpha2 domain, which both bind the peptide, exon 4 encodes thealpha3 domain, exon 5 encodes the transmembrane region, and exons 6and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 andexon 3 are responsible for the peptide binding specificity of eachclass one molecule. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. Over one hundredHLA-C alleles have been described
Other Names:
HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7, HLA-C, HLAC
Target/Specificity:
This HLA-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
Antigen Region:
66-93
Antigen Type: Synthetic Peptide
Gene Name: HLA-C (HGNC:4933)
Gene ID: 3107
Primary Accession: P10321
NCBI Accession: NP_002108.4
Other Accession: Q29865; Q95604; Q29960; P30510; P30508; P30505; Q29963; Q9TNN7; P30504; P04222; P30484; NP_002108.4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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