HLA-DMA antibody (clone 3F12-F11), anti-human
€435.00
In stock
SKU
AC-AT2375a
Catalog Number: AC-AT2375a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IHC, E
Request Information AC-AT2375a">Request Information
Background:
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Other Names:
HLA class II histocompatibility antigen, DM alpha chain, MHC class II antigen DMA, Really interesting new gene 6 protein, HLA-DMA, DMA, RING6
Antigen Type:
Recombinant Protein
Gene Name: HLA-DMA
Primary Accession: P28067
Other Accession: BC011447
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Other Names:
HLA class II histocompatibility antigen, DM alpha chain, MHC class II antigen DMA, Really interesting new gene 6 protein, HLA-DMA, DMA, RING6
Antigen Type:
Recombinant Protein
Gene Name: HLA-DMA
Primary Accession: P28067
Other Accession: BC011447
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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