HLA-DMB Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP18052c
Background:
HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta (DMB) chain, both anchored in the membrane. It islocated in intracellular vesicles. DM plays a central role in thepeptide loading of MHC class II molecules by helping to release theCLIP (class II-associated invariant chain peptide) molecule fromthe peptide binding site. Class II molecules are expressed inantigen presenting cells (APC: B lymphocytes, dendritic cells,macrophages). The beta chain is approximately 26-28 kDa and itsgene contains 6 exons. Exon one encodes the leader peptide, exons 2and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail.
Other Names:
HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7
Gene Name: HLA-DMB
Gene ID: 3109
Primary Accession: P28068
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta (DMB) chain, both anchored in the membrane. It islocated in intracellular vesicles. DM plays a central role in thepeptide loading of MHC class II molecules by helping to release theCLIP (class II-associated invariant chain peptide) molecule fromthe peptide binding site. Class II molecules are expressed inantigen presenting cells (APC: B lymphocytes, dendritic cells,macrophages). The beta chain is approximately 26-28 kDa and itsgene contains 6 exons. Exon one encodes the leader peptide, exons 2and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail.
Other Names:
HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7
Gene Name: HLA-DMB
Gene ID: 3109
Primary Accession: P28068
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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