HLA DMB polyclonal, anti-human

Quantity: 100 µg

Background:
HLA-DMB(major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is encoded by the HLA-DMB gene. The HLA-DMB gene is mapped on 6p21.32. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta(DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP(class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation.

Description:
Rabbit IgG polyclonal antibody for HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) detection. Tested with WB, IHC-P in Human.

Synonyms:
class II antigen HLA-DM beta chain antibody, class II histocompatibility antigen antibody, Class II histocompatibility antigen M beta chain antibody, D6S221E antibody, DMB antibody, HLA class II histocompatibility antigen DM beta chain antibody, HLA-DM histocompatibility type, beta chain antibody, M beta chain antibody, Major histocompatibility complex class II DM beta antibody, MHC class II antigen DMB antibody, MHC class II antigen HLA DM beta chain antibody, MHC class II HLA DMB antibody, OTTHUMP00000029257 antibody, Really interesting new gene 7 protein antibody, RING 7 antibody, RING7 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human HLA DMB(81-100aa NQKDTLMQRLRNGLQNCATH).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.