HLA-DMB polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP16546c
Catalog Number: AC-AP16546c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB36087
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB36087
Applications: WB
Datasheet
Request Information
Background:
HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta (DMB) chain, both anchored in the membrane. It islocated in intracellular vesicles. DM plays a central role in thepeptide loading of MHC class II molecules by helping to release theCLIP (class II-associated invariant chain peptide) molecule fromthe peptide binding site. Class II molecules are expressed inantigen presenting cells (APC: B lymphocytes, dendritic cells,macrophages). The beta chain is approximately 26-28 kDa and itsgene contains 6 exons. Exon one encodes the leader peptide, exons 2and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail.
Other Names:
HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7
Target/Specificity:
This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB.
Antigen Region:
104-133
Antigen Type: Synthetic Peptide
Gene Name: HLA-DMB
Gene ID: 3109
Primary Accession: P28068
NCBI Accession: NP_002109.2
Other Accession: NP_002109.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta (DMB) chain, both anchored in the membrane. It islocated in intracellular vesicles. DM plays a central role in thepeptide loading of MHC class II molecules by helping to release theCLIP (class II-associated invariant chain peptide) molecule fromthe peptide binding site. Class II molecules are expressed inantigen presenting cells (APC: B lymphocytes, dendritic cells,macrophages). The beta chain is approximately 26-28 kDa and itsgene contains 6 exons. Exon one encodes the leader peptide, exons 2and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail.
Other Names:
HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7
Target/Specificity:
This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB.
Antigen Region:
104-133
Antigen Type: Synthetic Peptide
Gene Name: HLA-DMB
Gene ID: 3109
Primary Accession: P28068
NCBI Accession: NP_002109.2
Other Accession: NP_002109.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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