HLA-DPA1 antibody (clone 1000), anti-human
€435.00
In stock
SKU
AC-AT2376a
Catalog Number: AC-AT2376a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT2376a">Request Information
Background:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Other Names:
HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1, HLA-DPA1, HLA-DP1A, HLASB
Antigen Type:
Recombinant Protein
Gene Name: HLA-DPA1
Gene ID: 3113
NCBI Accession: NP_001229453.1;NP_001229454.1;NP_291032.2
Primary Accession: P20036
Other Accession: BC009956
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Other Names:
HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1, HLA-DPA1, HLA-DP1A, HLASB
Antigen Type:
Recombinant Protein
Gene Name: HLA-DPA1
Gene ID: 3113
NCBI Accession: NP_001229453.1;NP_001229454.1;NP_291032.2
Primary Accession: P20036
Other Accession: BC009956
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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