HLA-DPA1 (clone 6C3D8), anti-human, rat
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In stock
SKU
BT-MCA2293
Catalog Number: BT-MCA2293
Size(s): 50μL, 100μL
Isotype: Mouse IgG2b
Reactivity: human, rat
Application(s): IHC, FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG2b
Reactivity: human, rat
Application(s): IHC, FCM
Datasheet
Request Information
Background:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Research Area: Others
Synonyms: DPA1, PLT1, HLADP, HLASB, DP(W3), DP(W4), HLA-DPA, HLA-DP1A, HLA-DPB1
Immunogen: Purified recombinant fragment of human HLA-DPA1 (AA: 29-209) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Research Area: Others
Synonyms: DPA1, PLT1, HLADP, HLASB, DP(W3), DP(W4), HLA-DPA, HLA-DP1A, HLA-DPB1
Immunogen: Purified recombinant fragment of human HLA-DPA1 (AA: 29-209) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
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