HLA-DPA1 Polyclonal Antibody

Background:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Research Area: Cancer, Immunology

Synonyms:
DP(W3), DP(W4), HLA class II histocompatibility antigen DP alpha 1 chain, HLA class II histocompatibility antigen DP alpha chain , HLA DP1A, HLA DPA 1, HLA SB alpha chain, HLADP, HLADPA1 , HLASB, HLASB histocompatibility type, Human MHC class II HLA SB alpha gene, Major histocompatibility complex class II DP alpha 1, MHC class II antigen, MHC class II DP3 alpha, MHC class II DPA1, MHC class II HLA DPA1 antigen, PLT1, Primed lymphocyte test 1

Immunogen: Synthetic peptide of human HLA-DPA1

Swissprot: P20036
Gene Accession: NP291032

Calculated MW: 29 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.