HLA-DPB1 antibody (clone 6C6), anti-human
€435.00
In stock
SKU
AC-AT2377a
Catalog Number: AC-AT2377a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IP, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IP, E
Request Information AC-AT2377a">Request Information
Background:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Other Names:
HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B
Antigen Type:
Recombinant Protein
Gene Name: HLA-DPB1
Gene ID: 3115
NCBI Accession: NP_002112.3
Primary Accession: P04440
Other Accession: BC013184
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Other Names:
HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B
Antigen Type:
Recombinant Protein
Gene Name: HLA-DPB1
Gene ID: 3115
NCBI Accession: NP_002112.3
Primary Accession: P04440
Other Accession: BC013184
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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