HLA-DPB1 polyclonal, anti-human, mouse, rat

Background:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Synonyms: DPB1, HLA-DP, HLA-DP1B, HLA-DPB

Cellular Location: Cell membrane Endoplasmic reticulum membrane Endosome membrane Golgi apparatus Lysosome membrane Single-pass type I membrane protein trans-Golgi network membrane

Immunogen:
Recombinant protein of human HLA-DPB1

Gene Symbol: HLA-DPB1

Gene ID: 3115

Swiss prot: P04440

Calculated MW: 29kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.