HLA-DPB1 Polyclonal Antibody

Background:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Research Area: Cancer, Immunology

Synonyms:
D6S221E, DMA, DMB, DP beta 1, DP beta 1 chain, DP(W4) beta chain, DPB 1, DPB1, DPB1, DRB, H2Ea, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DM beta chain , HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, HLA DMB, HLA DP1A, HLA DPB1, HLA SB alpha chain, HLA-A, HLA-A histocompatibility type, HLA-DP, HLA-DP histocompatibility type, beta-1 subunit, HLA-DP1B, HLA-DPB, HLA-DPB1, HLADM, HLADP1B, HLASB, HLASB histocompatibility type, Human MHC class II HLA SB alpha, LA class II histocompatibility antigen DP alpha 1 chain, Major histocompatibility complex class II, Major histocompatibility complex class II DP alpha 1, Major histocompatibility complex class II DP beta 1, Major histocompatibility complex, class I, A, MHC class II antigen DMB, MHC class II antigen DPB1, MHC class II DP3 alpha, MHC class II DPA1, MHC class II HLA-DP-beta-1, MHC DPB1, MHC HLA DPB1, PLT1, Primed lymphocyte test 1, RING6, RING7

Immunogen: Fusion protein of human HLA-DPB1

Swissprot: P04440
Gene Accession: BC015000

Calculated MW: 29 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:20-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.