HLA DQ (clone NKI(SPV)L3), anti-human, swine
€564.00
In stock
SKU
ARP-21-5088
Catalog Number: 21-5088
Size: 100 µg
Isotype: Mouse IgG2a
Size: 100 µg
Isotype: Mouse IgG2a
Background:
HLA-DQ (DQ) is a cell surface receptor type protein found on antigen presenting cells. DQ is an alphabeta heterodimer of the MHC Class II type. The alpha and beta chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the alpha-chain and beta-chain vary greatly. A person often produces two alpha-chain and two beta-chain variants and thus 4 DQ isoforms. The DQ loci are in close genetic linkage to HLA-DR but less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. DQ functions on antigen presenting cells, and is an antigen presenting molecule. Different DQ isoforms can bind to and present different antigens to T-cells. In this process T-cells are stimulated to grow and can signal B-cells to produce antibodies. DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants. As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people.
Clone: NKI(SPV)L3
Isotype: Mouse IgG2a
Reactivity: human, swine
Specificity: NKI(SPV)L3 reacts with a monomorphic determinant on HLA-DQ (MHC class II).
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunohistochemistry (frozen), Immunoprecipitation
Storage: Store at 4C, or in small aliquots at -20C.
HLA-DQ (DQ) is a cell surface receptor type protein found on antigen presenting cells. DQ is an alphabeta heterodimer of the MHC Class II type. The alpha and beta chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the alpha-chain and beta-chain vary greatly. A person often produces two alpha-chain and two beta-chain variants and thus 4 DQ isoforms. The DQ loci are in close genetic linkage to HLA-DR but less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. DQ functions on antigen presenting cells, and is an antigen presenting molecule. Different DQ isoforms can bind to and present different antigens to T-cells. In this process T-cells are stimulated to grow and can signal B-cells to produce antibodies. DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants. As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people.
Clone: NKI(SPV)L3
Isotype: Mouse IgG2a
Reactivity: human, swine
Specificity: NKI(SPV)L3 reacts with a monomorphic determinant on HLA-DQ (MHC class II).
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunohistochemistry (frozen), Immunoprecipitation
Storage: Store at 4C, or in small aliquots at -20C.
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