HLA-DQB1 Polyclonal Antibody

Background:
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.

Research Area: Immunology

Synonyms:
CELIAC1, DQ beta 1 chain, DQB1, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen, DQ beta 1 chain, HLA class II histocompatibility antigen, DQ beta 2 chain, HLA DQB, HLA DQB1, HLA-DQB1, HLA-DQB2, IDDM1, Lymphocyte antigen, Major histocompatibility complex class II beta, Major histocompatibility complex, class II, DQ beta 1, MHC class II antigen DQB1, MHC class II antigen HLA DQ beta 1, MHC class II DQ beta chain, MHC class II HLA DQ beta glycoprotein, MHC class2 antigen, MHC DQ beta, OTTHUMP00000029167, OTTHUMP00000178569, OTTHUMP00000178570, OTTHUMP00000178571

Immunogen: Fusion protein of human HLA-DQB1

Swissprot: P01920
Gene Accession: BC012106

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.48 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.