HLA-DQB2 Polyclonal Antibody

Background:
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.

Research Area: Immunology

Synonyms:
DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)), DX-beta, HLA class II histocompatibility antigen, DQ beta 2 chain, HLA class II histocompatibility antigen, DX beta chain, HLA DQB1, HLA DXB, major histocompatibility complex, class II, DQ beta 1, Major histocompatibility complex, class II, DQ beta 2, Major histocompatibility complex, class II, DX beta, MHC class II antigen DQB2

Immunogen: Fusion protein of human HLA-DQB2

Swissprot: P05538
Gene Accession: BC031995

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.26 mg/mL
Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.