HLA-DRA (clone # 302CT2.3.2), anti- antibody
€275.00
In stock
SKU
AC-ABV11330-50
Catalog Number: AC-ABV11330-50
Size: 50 µl
Host: Mouse IgG
Applications: WB
Datasheet
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Size: 50 µl
Host: Mouse IgG
Applications: WB
Datasheet
Request Information
Background:
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II å/∫ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (∫-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Other Names:
HLA-DRA, HLA-DRA1, HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen DRA
Primary Accession: P01903
Gene Name: HLA-DRA
Gene ID: 3122
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II å/∫ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (∫-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Other Names:
HLA-DRA, HLA-DRA1, HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen DRA
Primary Accession: P01903
Gene Name: HLA-DRA
Gene ID: 3122
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