HLA-DRB4 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13690a
Background:
HLA-DRB4 belongs to the HLA class II beta chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DRA) and a beta (DRB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The beta chain isapproximately 26-28 kDa and its gene contains 6 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andexon 5 encodes the cytoplasmic tail. Within the DR molecule thebeta chain contains all the polymorphisms specifying the peptidebinding specificities. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. DRB1 is expressedat a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB4 is linked with allelic variants of DRB1,otherwise it is omitted. There are 4 related pseudogenes: DRB2,DRB6, DRB7, DRB8 and DRB9.
Other Names:
HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13690a was selected from the N-term region of HLA-DRB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HLA-DRB4
Gene ID: 3126
Primary Accession: P13762
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
HLA-DRB4 belongs to the HLA class II beta chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DRA) and a beta (DRB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The beta chain isapproximately 26-28 kDa and its gene contains 6 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andexon 5 encodes the cytoplasmic tail. Within the DR molecule thebeta chain contains all the polymorphisms specifying the peptidebinding specificities. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. DRB1 is expressedat a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB4 is linked with allelic variants of DRB1,otherwise it is omitted. There are 4 related pseudogenes: DRB2,DRB6, DRB7, DRB8 and DRB9.
Other Names:
HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13690a was selected from the N-term region of HLA-DRB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HLA-DRB4
Gene ID: 3126
Primary Accession: P13762
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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