HLA-E Polyclonal Antibody

Background:
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Research Area: Cancer, Immunology

Synonyms:
HLA class I histocompatibility antigen E alpha chain, EA1.2, EA2.1, HLA 6.2, HLA class I histocompatibility antigen alpha chain E, HLA class I histocompatibility antigen E alpha chain precursor , HLA class I histocompatibility antigen E alpha chain precursor, HLA6.2, HLAE, Lymphocyte antigen, Major histocompatibility complex class I E, MHC, MHC class I antigen E, MHC HLA E alpha 1, MHC HLA E alpha 2.1, QA1

Immunogen: Fusion protein of human HLA-E

Swissprot: P13747
Gene Accession: BC002578

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.