HMGA2 Polyclonal Antibody

Background:
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Developmental biology, Neuroscience, Stem cells

Synonyms:
HMGA 2, BABL, High mobility group (nonhistone chromosomal) protein isoform I C, High mobility group (nonhistone chromosomal) protein isoform IC, High Mobility Group AT hook 2, High Mobility Group AT hook protein 2, High mobility group AT-hook protein 2, High mobility group protein HMGI C, High mobility group protein HMGI-C, High mobility group protein HMGIC, High mobility group protein I, isoform C, HMGA2, HMGA2, HMGI C, HMGIC, LIPO, Non histone chromosomal architectural protein HMGI C, Non histone chromosomal architectural protein HMGIC, Pygmy, STQTL9

Immunogen: Synthetic peptide of human HMGA2

Swissprot: P52926
Gene Accession: NP003474

Calculated MW: 12 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.02 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.