HMGB2 Polyclonal Antibody

Background:
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
C80539, High mobility group (nonhistone chromosomal) protein 2, High mobility group box 2, HMG 2, HMGB2

Immunogen: Recombinant Human High mobility group protein B2 protien

Swissprot: P26583

Calculated MW: 24 kDa
Observed MW: 24 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:1000 IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.