HMGCR Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP6577c
Background:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Other Names:
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6577c was selected from the Center region of human HMGCR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HMGCR (HGNC:5006)
Gene ID: 3156
Primary Accession: P04035
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Other Names:
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6577c was selected from the Center region of human HMGCR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HMGCR (HGNC:5006)
Gene ID: 3156
Primary Accession: P04035
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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