HMGCR polyclonal, anti-human, mouse, rat

Background:
The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.

Alternative Name:
HMG-CoA reductase, HMGCR, 3 hydroxy 3 methylglutaryl CoA reductase, 3 hydroxy 3 methylglutaryl Coenzyme A reductase, 3 hydroxymethylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3H3M, HMDH, HMG CoA reductase, HMG CoAR, HMG-CoA reductase, Hmgcr, Hydroxymethylglutaryl CoA reductase, LDLCQ3, MGC103269, Red,

Application Dilution:
WB:1:1,000-1:2,000

Specificity: HMGCR polyclonal antibody detects endogenous levels of HMGCR protein.

Immunogen:
recombinant protein

MW: 97 kDa

Swiss-Prot: P04035(Human) Q01237(Mouse) P51639(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.