HMGCR polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP6577c
Catalog Number: AC-AP6577c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19370
Applications: IHC-P, WB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19370
Applications: IHC-P, WB
Datasheet
Request Information
Background:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Other Names:
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR
Target/Specificity:
This HMGCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380~410 amino acids from the Center region of human HMGCR.
Antigen Region:
380-410
Antigen Type: Synthetic Peptide
Gene Name: HMGCR (HGNC:5006)
Gene ID: 3156
Primary Accession: P04035
NCBI Accession: NP_000850.1;NP_001124468.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Other Names:
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR
Target/Specificity:
This HMGCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380~410 amino acids from the Center region of human HMGCR.
Antigen Region:
380-410
Antigen Type: Synthetic Peptide
Gene Name: HMGCR (HGNC:5006)
Gene ID: 3156
Primary Accession: P04035
NCBI Accession: NP_000850.1;NP_001124468.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
|---|
Write Your Own Review