HNF1A Polyclonal Antibody

Background:
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Albumin proximal factor, Hepatic nuclear factor 1 alpha, Hepatic nuclear factor 1, Hepatic transcription factor 1 alpha, Hepatic transcription factor 1, Hepatocyte nuclear factor 1-alpha, HNF 1, HNF 1A, HNF-1-alpha, HNF-1A, hnf1a, HNF1A, Interferon production regulator factor, LF B1, LF B1 hepatic nuclear factor, LFB 1, LFB1, LFB1 hepatic nuclear factor, Liver specific transcription factor LF B1, Liver specific transcription factor LFB1, Liver-specific transcription factor LF-B1, Maturity onset diabetes of the young 3, MODY 3, MODY3, TCF 1, TCF-1, TCF1, Transcription factor 1, Transcription factor 1 hepatic

Immunogen: Synthetic peptide of human HNF1A

Swissprot: P20823
Gene Accession: NP000536

Calculated MW: 67 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.66 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.