HNF1B Polyclonal Antibody

Background:
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
FJHN, Hepatocyte nuclear factor 1 beta, Hepatocyte nuclear factor 1-beta, HNF 1B, HNF 2, HNF-1-beta, HNF-1B, HNF1 beta, HNF1 homeobox B, HNF1B, HNF1B, HNF1beta, HNF2, Homeoprotein LF B3, Homeoprotein LFB3, HPC11, LF B3, LFB3, MODY 5, MODY5, TCF 2, TCF 2 protein, TCF-2, TCF2, TCF2 protein, Transcription factor 2, Transcription factor 2 hepatic, Variant hepatic nuclear factor 1, Variant hepatic nuclear factor, VHNF 1, vHNF1

Immunogen: Synthetic peptide of human HNF1B

Swissprot: P35680
Gene Accession: NP_000449.1

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7411/sc-22840