HNF4A Polyclonal Antibody

Background:
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Developmental Biology, Signal Transduction

Synonyms:
FLJ39654, FRTS4, Hepatic nuclear factor 4 alpha, Hepatocyte nuclear factor 4 alpha, Hepatocyte nuclear factor 4, Hepatocyte nuclear factor 4-alpha, HNF 4 alpha, HNF 4, HNF-4-alpha, HNF4, HNF4A, HNF4A, HNF4a7, HNF4a8, HNF4a9, Hnf4alpha, HNF4alpha10/11/12, MODY 1, MODY, MODY1, NR2A1, NR2A21, Nuclear receptor subfamily 2 group A member 1, OTTHUMP00000031060, OTTHUMP00000031062, TCF 14, TCF, TCF-14, TCF14, Tcf4, Transcription factor 14, hepatic nuclear factor, Transcription factor 14, Transcription factor HNF 4, Transcription factor HNF-4, Transcription factor HNF4

Immunogen: Synthetic peptide of human HNF4A

Swissprot: P41235
Gene Accession: NP000448

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.sciencedirect.com/science/article/pii/S0891584918316691