HNMT Polyclonal Antibody

Background:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

Research Area: Cancer, Neuroscience

Synonyms:
HNMT, HMT, HNMT-S1, HNMT-S2, MRT51

Immunogen: Recombinant fusion protein of human HNMT (NP_008826.1).

Swissprot: P50135
Gene ID: 3176

Calculated MW: 6 kDa/14 kDa/33 kDa
Observed MW: 33 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.