HNMT polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP1442A
Catalog Number: AC-AP1442A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB12380
Applications: IHC-P, WB, IF
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB12380
Applications: IHC-P, WB, IF
Datasheet
Request Information
Background:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
Other Names:
Histamine N-methyltransferase, HMT, HNMT
Target/Specificity:
This HNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human HNMT.
Antigen Region:
29-58
Antigen Type: Synthetic Peptide
Gene Name: HNMT
Gene ID: 3176
Primary Accession: P50135
NCBI Accession: NP_001019245.1;NP_001019246.1;NP_008826.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
Other Names:
Histamine N-methyltransferase, HMT, HNMT
Target/Specificity:
This HNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human HNMT.
Antigen Region:
29-58
Antigen Type: Synthetic Peptide
Gene Name: HNMT
Gene ID: 3176
Primary Accession: P50135
NCBI Accession: NP_001019245.1;NP_001019246.1;NP_008826.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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