HNP-1 (clone ), anti-human, rat

Background:
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Alternative Name:
HP-1, HP1, HP-2, HP2, DEFA1, DEF1, DEFA2, MRS, alpha 1, DEF1, DEF1, DEFA1, DEFA1B, DEFA2, Defensin 1, Defensin, Defensin, alpha 1, Defensin, alpha 1, myeloid related sequence, Defensin, alpha 2, HNP-1, HNP-2, HNP1, HP-1, HP-2, HP1, HP2, MRS, Myeloid related sequence, Neutrophil defensin 1, Neutrophil defensin 2,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200

Specificity: HNP-1 monoclonal antibody detects endogenous levels of HNP-1 protein.

Immunogen:
Peptide

MW: 10 kDa

Swiss-Prot: P59665(Human)

Purification & Purity:
ProG affinity purified

Format:
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.