hnRNP A2/B1 polyclonal antibody, anti-human, mouse

Background:
HNRNPA2B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. Heterogeneous nuclear ribonucleoproteins A2/B1 encoded by HNRNPA2B1 has two repeats of quasi-RRM domains that bind to RNAs. HNRNPA2B1 has been described to generate two alternatively spliced transcript variants which encode different isoforms.

Research Area: Epigenetics and Nuclear Signaling

Synonyms: HNRNPA2B1, HNRPA2B1, Heterogeneous nuclear ribonucleoproteins A2/B1, hnRNP A2/B1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year