hnRNP K polyclonal, anti-human, mouse, rat

Background:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of poly-peptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA Polymerase II. There are approximately 20 known hnRNP proteins and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein are localized to the nucleus, however some shuttle between the nucleus and the cytoplasm, such as hnRNP K. hnRNP K recruits a variety of molecular partners through two K homologous (KH) domains, which are required for protein-protein interactions. hnRNP K also contains several potential phosphorylation sites, including Ser 302, the major site of PKCd phosphorylation, which are thought to regulate various cellular functions, including sequence-specific DNA binding, transcription, RNA binding and nucleocytoplasmic shuttling.

Alternative Name:
hnRNP K, TUNP, HNRNPK, CSBP, dC stretch binding protein, FLJ41122, Heterogeneous nuclear ribonucleoprotein K, hnRNP K, HNRNPK, HNRPK, HNRPK, Transformation up regulated nuclear protein, Transformation up-regulated nuclear protein, Transformation upregulated nuclear protein, TUNP,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: hnRNP K polyclonal antibody detects endogenous levels of hnRNP K protein.

Immunogen:
recombinant protein

MW: 60 kDa

Swiss-Prot: P61978(Human) P61979(Mouse) P61980(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.